(16) He withdrew himself into the wilderness.--Literally, into the wildernesses, agreeing with St. Mark's "in desert places," now in one part, now in another, of the unenclosed, uncultivated country. The addition that he "was praying" there is peculiar to St. Luke, who, throughout his Gospel, lays stress on this feature in our Lord's life. (See Introduction.)

5:12-16 This man is said to be full of leprosy; he had that distemper in a high degree, which represents our natural pollution by sin; we are full of that leprosy; from the crown of the head to the sole of the foot there is no soundness in us. Strong confidence and deep humility are united in the words of this leper. And if any sinner, from a deep sense of vileness, says, I know the Lord can cleanse, but will he look upon such a one as me? will he apply his own precious blood for my cleansing and healing? Yes, he will. Speak not as doubting, but as humbly referring the matter to Christ. And being saved from the guilt and power of our sins, let us spread abroad Christ's fame, and bring others to hear him and to be healed.And he withdrew himself into the wilderness,.... Into a desert place, that he might have rest from the fatigues of preaching and healing diseases; and being alone, and free from company, might have an opportunity for private prayer to God, for so it lows:

and prayed; this is to be understood of Christ, as man: as God, he is the object of prayer, and petitions are often addressed unto him; and as mediator, he offers up the prayers of all saints, and presents them to his Father; which are acceptable to him, through the incense of his mediation; and as man, he prayed himself: what he now prayed for, is not known; sometimes he prayed for his disciples, and for all that should believe; for their conversion, sanctification, union, perseverance, and glorification; and sometimes for himself, that the cup might pass from him, and he be saved from death; but always with submission to the will of his Father.