(6) They shall die of a great pestilence.--This was doubtless, as in other instances (Thuc. ii. 52), the natural consequence of the siege, but it came before the people as another proof that Jehovah had stretched out his arm against them, that they were fighting against that arm as well as against the host of the invaders. The "outstretched hand" may be noted as another Deuteronomic phrase (Deuteronomy 4:34; Deuteronomy 5:15; Deuteronomy 26:8).

21:1-10 When the siege had begun, Zedekiah sent to ask of Jeremiah respecting the event. In times of distress and danger, men often seek those to counsel and pray for them, whom, at other times, they despise and oppose; but they only seek deliverance from punishment. When professors continue in disobedience, presuming upon outward privileges, let them be told that the Lord will prosper his open enemies against them. As the king and his princes would not surrender, the people are exhorted to do so. No sinner on earth is left without a Refuge, who really desires one; but the way of life is humbling, it requires self-denial, and exposes to difficulties.And I will smite the inhabitants of this city,.... With one or other of his arrows after mentioned: or, "them that abide in this city" (o); that do not go out of it, and surrender themselves to the king of Babylon; see Jeremiah 21:9;

both man and beast; the latter for the sin of the former; particularly such beasts as were fit for food are meant, whereby the famine would be increased, and so the greater destruction of men:

they shall die of a great pestilence; both man and beast; a disease which comes immediately from the hand of God; hence Hippocrates used to call it , "the divine disease": here it denotes a very uncommon one, which should sweep away large numbers; called great, both for quality, or the nature of it, and for the quantity of persons that died of it.

(o) "manentes in hac urbe", Gataker.